Conférence de Lorenzo Tattini

Conference : Evolutionary Landscapes in the Era of Complete Genomes.

Genome evolution can occur on different molecular- and time-scales. Single-nucleotide polymorphisms as well as short insertions and deletions have been thoroughly investigated by means of short-read sequencing technologies. These resequencing approaches are based on a reference genome and have been shown to suffer from the reference bias which prevents the accurate investigation of gene flow between closely related species (through introgression) and distantly related organisms (via horizontal gene transfer).

These limits have been overcome using long-read sequencing technologies that provide de novo complete genomes and also allow for the detailed investigation of structural variants. These end-to-end assemblies can be combined in a pangenome variation graph that captures both core and accessory features along with the full spectrum of genomic variation, highlighting the evolutionary forces that shape genomes and potentially lead to speciation.

In this seminar, I will walk you through the pangenomic evolutionary landscape of yeast taking advantage of complete genome sequences to reveal the adaptive implications of genomic variation and to underline its different molecular- and time-scales.